NHLS DGM

Chemistry

Assay	Units	Sex	Low Range	High Range
Sodium	mmol/L		136	145
Potassium	mmol/L		3.5	5.1
Chloride	mmol/L		98	113
Chloride	mmol/L		98	107
Bicarbonate	mmol/L		23	29
Urea	mmol/L		2.1	7.1
Creatinine	umol/L	M	64	104
Creatinine	umol/L	F	49	90
Lactate	mmol/L		0.5	2.2
Ammonia	umol/L		11	35
Calcium	mmol/L		2.15	2.5
Magnesium	mmol/L		0.63	1.05
Inorganic phosphate	mmol/L		0.78	1.42
Uric acid	mmol/L	M	0.21	0.43
Uric acid	mmol/L	F	0.16	0.36
Total protein	g/L		60	78
Albumin	g/L		35	52
Total bilirubin	umol/L		5	21
Conjugated bilirubin (DBil)	umol/L		0	5
Conjugated bilirubin (DBil)	umol/L		0	3
Alanine transaminase (ALT)	U/L	M	10	40
Alanine transaminase (ALT)	U/L	F	7	35
Aspartate transaminase (AST)	U/L	M	15	40
Aspartate transaminase (AST)	U/L	F	13	35
Alkaline phosphatase (ALP)	U/L	M	53	128
Alkaline phosphatase (ALP)	U/L	F	42	98
Gamma-glutamyl transferase (GGT)	U/L	M	<68
Gamma-glutamyl transferase (GGT)	U/L	F	<40
Lactate dehydrogenase (LD)	U/L		100	190
Lactate dehydrogenase (LD)	U/L		110	210
Creatine kinase (CK)	U/L	M	20	200
Creatine kinase (CK)	U/L	F	20	180
Amylase	U/L		20	104
Lipase	U/L		13	60
C-Reactive protein	mg/L		<10
Complement C3	g/L		0.9	1.8
Complement C4	g/L		0.1	0.4
Iron	umol/L	M	11.6	31.3
Iron	umol/L	F	9	30.4
Transferrin	g/L	M	2.15	3.65
Transferrin	g/L	F	2.5	3.8
Acetaminophen / Paracetamol	umol/L		66	132
Phenytoin / Epanutin	umol/L		40	80
Phenobarbital	umol/L		65	172
Carbamazepine / Tegretol	umol/L		17	51
Valproate / Epilim	umol/L		346	693
Digoxin / Lanoxin	nmol/L		1	2.6
Theophylline / Aminophylline	umol/L		56	111
Urine amylase	U/L	(Age: 0-39)	17	494
Urine amylase	U/L	(Age: >39)	27	595
CSF chloride	mmol/L		118	132
CSF protein	g/L		0.15	0.45
CSF lactate	mmol/L		1	2.9
Creatine kinase MB mass (CK-MB)	ug/L		0	5
Beta 2-microglobulin	mg/L		0.6	2.4
Immunoglobulin G	g/L		6.5	16
Immunoglobulin A	g/L		0.4	3.5
Immunoglobulin M	g/L		0.5	3
Ferritin	ug/L	M	22	322
Ferritin	ug/L	F	10	291
Vitamin B12	pmol/L		156	672
Serum folate	nmol/L		>12.2
Beta-HCG	IU/L		0	9
Alpha-feto protein (AFP)	ug/L		0	8
CA 19-9	kU/L		0	31
Thyroid stimulating hormone	mIU/L		0.55	4.78
Thyroxine (free T4)	pmol/L		11.5	22.7
Tri-iodo thyronine (free T3)	pmol/L		3.5	6.5
Follicle stimulating hormone	IU/L	M	1.4	18.1
Follicle stimulating hormone	IU/L	F	23	116.3
Luteinising hormone	IU/L	F	7.9	53.8
Luteinising hormone	IU/L	M	1.5	9.3
Oestradiol (E2)	pmol/L	M	0	146
Oestradiol (E2)	pmol/L	F	0	118
Progesterone	nmol/L	M	0.9	3.9
Progesterone	nmol/L	F	0	2.3
Testosterone	nmol/L	M (Age:18-49)	6.9	23.2
Testosterone	nmol/L	M (Age>49)	6.5	23.7
Testosterone	nmol/L	F (Age:18-49)	0.3	1.2
Testosterone	nmol/L	F (Age>49)	0.2	1.3
Sex hormone binding globulin (SHBG)	nmol/L	F (Age:18-49)	17.7	138.3
Sex hormone binding globulin (SHBG)	nmol/L	F (Age>49)	23.7	110.6
Sex hormone binding globulin (SHBG)	nmol/L	M (Age:18-49)	11.5	54.5
Sex hormone binding globulin (SHBG)	nmol/L	M (Age>49)	17.3	71.5
Free androgen index		F (Age:18-49)	0.3	4.4
Free androgen index		F (Age>49)	0.3	2.5
Insulin	mIU/L		3	25
C-peptide	ug/L		0.8	3.9
Prolactin	ug/L	M	2.1	17.7
Prolactin	ug/L	F	1.8	20.3
Parathyroid hormone (PTH)	pmol/L		2	8.5
Interleukin 6	pg/mL		<4.4
Anti-thyroid peroxidase Ab	U/mL		0	60
dU cortisol	nmol/24 hrs		58	807
Prostate-specific Ag (PSA)	ug/L		<4
Carcinoembryonic Ag (CEA)	ug/L		0	5
CA 125	kU/L		0	35
CA 15-3	kU/L		0	32.4
CA 19-9	kU/L		0	39
AFP	kU/L		0	5.8
Beta-HCG	IU/L		<5
Vitamin B12	pmol/L		145	569
Vitamin D	nmol/L		>30

Please note that the ranges given above are only suitable for adults above 18 years of age.

Chemistry

1. Troponin I	cTroponin I interpretation in suspected Acute Coronary Syndrome (ACS): Rule-in ACS: Value >600 ng/L (WHO rule-in level) Rule-out ACS: Value ≤38 ng/L (females) ≤53 ng/L (males) (99th percentile level), if more than 6hrs after onset of chest pain Less than 6hrs of chest pain and values < rule-in level requires repeat sampling 3 hours later to demonstrate a rise in value. Note that Troponin results obtained from different instruments have different cut-off values and are NOT comparable. This result was obtained using a Siemens Atellica instrument.
2. Serum Folate	Serum folate: Deficient levels < 7.6 nmol/L
3. B-hCG	Beta-hCG values during pregnancy (when performed on a Siemens Atellica analyzer): < 10 IU/L: Negative 10 - 25 IU/L: Indeterminate > 25 IU/L: Positive Approximate Gestational Age and HCG range: 2 - 4 weeks: 39 - 8,388 5 - 6 weeks: 861 - 88,769 6 - 8 weeks: 8,636 - 218,085 8 - 10 weeks: 18,700 - 244,467 10 - 12 weeks: 23,143 - 181,899 13 - 27 weeks: 6,303 - 97,171 28 - 40 weeks: 4,360 - 74,883
4. Alpha Fetoprotein	AFP values in pregnancy (when performed on a Siemens Atellica analyzer): 15 weeks: Median 31.3 ug/L, MoM x 2 62.6, MoM x 2.5 78.3 16 weeks: Median 36.3 ug/L, MoM x 2 72.6, MoM x 2.5 90.8 17 weeks: Median 42.0 ug/L, MoM x 2 84.0, MoM x 2.5 105.0 18 weeks: Median 48.7 ug/L, MoM x 2 97.4, MoM x 2.5 121.8 19 weeks: Median 56.5 ug/L, MoM x 2 113.0, MoM x 2.5 141.3 20 weeks: Median 65.4 ug/L, MoM x 2 130.8, MoM x 2.5 163.5 (MoM = Multiples of the median) Gestational age-related reference ranges for AFP are used to aid the diagnosis of Neural Tube Defect (NTD) and Down's syndrome (in combination with multiple serum markers eg hCG and estriol). Any AFP value >2 times the median should be investigated by ultrasound examination to exclude foetal malformations as well as multiple gestation, foetal death and incorrectly estimated gestational age. Reference: Tietz Clinical Guide to Laboratory Tests 4th Edition pg 401, and manufacturer's package insert. NB. Medians not locally derived. Ref: Atellica package insert
5. Cortisol	Cortisol reference intervals (when performed on a Siemens Atellica analyzer): Morning (07:00-09:00): 145 - 619 nmol/L Afternoon (15:00-17:00): 95 - 462 nmol/L Ref: Atellica package insert
6. FSH	FSH reference intervals for women (when performed on a Siemens Atellica analyzer): Mid-follicular phase: 2.5 - 10.2 IU/L Mid-cycle peak: 3.4 - 33.4 IU/L Mid-luteal phase: 1.5 - 9.1 IU/L Postmenopausal: 23.0 - 116.3 IU/L Pregnant: < 0.3 IU/L Ref: Atellica package insert
7. LH	LH reference intervals for women (when performed on a Siemens Atellica analyzer): Mid-follicular phase: 2.0 - 12.0 IU/L Mid-cycle peak: 12.0 - 90.0 IU/L Mid-luteal phase: 1.0 - 11.0 IU/L Postmenopausal: 7.7 - 58.0 IU/L Pregnant: < 0.3 IU/L Ref: Atellica package insert
8. TSH	TSH reference intervals (when performed on a Siemens Atellica analyzer): Adult: 0.27 - 4.20 mIU/L Pregnant: 0.10 - 2.50 mIU/L Ref: Atellica package insert
9. FT4	FT4 reference intervals (when performed on a Siemens Atellica analyzer): Adult: 11 - 23 pmol/L Pregnant: 10 - 19 pmol/L Ref: Atellica package insert
10. FT3	FT3 reference intervals (when performed on a Siemens Atellica analyzer): Adult: 3.5 - 6.5 pmol/L Pregnant: 3.0 - 6.0 pmol/L Ref: Atellica package insert
11. Oestradiol	Oestradiol reference intervals for women (when performed on a Siemens Atellica analyzer): Follicular (-12 to -4d): 72 - 529 pmol/L Mid-cycle (-3 to +2d): 235 - 1309 pmol/L Luteal (+4 to +12d): 205 - 786 pmol/L Postmenopausal: < 118 pmol/L Ref: Atellica package insert
12. Progesterone	Progesterone reference intervals for women (when performed on a Siemens Atellica analyzer): Mid-follicular phase: < 4.5 nmol/L Mid-cycle phase: 10.6 - 81.3 nmol/L Mid-luteal phase: 14.1 - 89.1 nmol/L Postmenopausal: < 2.3 nmol/L Pregnancy 1st trimester: 35.7 - 286.2 nmol/L Pregnancy 2nd trimester: 81.3 - 284.3 nmol/L Pregnancy 3rd trimester: 153.9 - 1343.6 nmol/L Ref: Atellica package insert
13. Testosterone	Testosterone reference intervals for women (when performed on a Siemens Atellica analyzer): Premenopause: 0.4 - 2.1 nmol/L Postmenopause: < 0.2 - 1.7 nmol/L Ref: Atellica package insert
14. SHBG	SHBG reference intervals for women (when performed on a Siemens Atellica analyzer): Premenopause: 10.8 - >180 nmol/L Postmenopause: 23.2 - 159.1 nmol/L Ref: Atellica package insert
15. Prolactin	Non-pregnant: 2.8 - 29.2 ug/L Pregnant: 9.7 - 208.5 ug/L Postmenopausal: 1.8 - 20.3 ug/L
16. Amniotic Fluid AFP	Amniotic fluid AFP values in pregnancy (when performed on a Siemens Atellica analyzer): Gestational Age \| Median (ug/L) \| MoM x 2 \| MoM x 2.5 15 weeks \| 17.3 \| 34.6 \| 43.3 16 weeks \| 14.3 \| 28.6 \| 35.8 17 weeks \| 11.9 \| 23.8 \| 29.8 18 weeks \| 9.8 \| 19.6 \| 24.5 19 weeks \| 8.1 \| 16.2 \| 20.3 20 weeks \| 6.7 \| 13.4 \| 16.8 Gestational age-related reference ranges for AFP are used to aid the diagnosis of Neural Tube Defect (NTD) and Down's syndrome. Any AFP value >2 times the median should be investigated by ultrasound examination to exclude foetal malformations as well as multiple gestation, foetal death and incorrectly estimated gestational age. Ref: Atellica package insert

Chemistry

Blood	CSF
Sodium	Protein
Potassium	Glucose
Urea	B2 Transferrin
Creatinine
Glucose
Total Bilirubin
LFT (AST, ALP, GGT, LDH and Dbil)
Calcium
Magnesium
Phosphate
Troponin
CRP (C-reactive protein)
Serum Osmolality
Cortisol
Quantitative BhCG
Cholinesterase
Amylase/Lipase
Acetaminophen
Salicylate
Immunosuppressant’s: Cyclosporine, Tacrolimus, Methotrexate, Sirolimus, Everolimus
B-HCG
TSH
Lactate
Lithium
Digoxin
PBG
Other suspected drug toxicities